Genetic variation in nature

Genetic variation of Japanese encephalitis virus in nature.

Forty-six strains of Japanese encephalitis (JE) virus from a variety of geographic areas in Asia were examined by primer-extension sequencing of the RNA template. A 240 nucleotide sequence from the pre-M gene region was selected for study because it provided sufficient information for determining genetic relationships among the virus isolates. Using 12% divergence as a cutoff point for virus re...

Evolutionary Genetics: The Nature of Hidden Genetic Variation Unveiled

All life on earth owes its existence to genetic accidents — mutations. Without genetic variation, no evolution would be possible and hence life as we know it would not exist. Also existing life forms would be doomed in the long run if there were not a steady stream of genetic novelties that allow species to adapt to changing environmental conditions, such as ice ages or global warming. Yet gene...

P-199: Genetic Variation Analysis of MIF in Endometriosis Patients

Background: Macrophage migration inhibitory factor (MIF) is a key pro-inflammatory cytokine that is secreted by active macrophages accumulated in ectopic tissue of endometriosis. It involves in pathophysiological events of endometriosis such as angiogenesis, cell proliferation and it can stimulate the synthesis of PGE2 that are necessary for survival and establishment of ectopic endometriosis t...

Genetic Variation of Choline Dehydrogenase Gene in Idiopathic Male Infertility

Infertility can be caused by an unexplained reduction in semen quality in males who present asnormal on physical examination and endocrine testing. There is some evidence that aberrantmetabolism of micronutrients such as choline may play a causative role in male factorinfertility. Choline is a crucial factor in the regulation of sperm membrane structure andmotility, and this nutrient plays an i...

Genetic Variation in MMP-1 Promoter Region and